You should not take Zyrtec-D and NyQuil together. The drugs willinteract differently when you take them together. You should talkwith your doctor before taking them together. The drugs. Can you take Nyquil with Zyrtec? Update. you could just skip the Zyrtec and take Nyquil. 3.6k Views. Related Questions. Can you take Zyrtec and Singulair? Can you take Mucinex and Zyrtec together? Can I take NyQuil and Aleve together? Can Tylenol and Zyrtec be taken simultaneously? Can you take Zyrtec and Mucinex D together? What happens if you take Zyrtec and Benadryl together? Can I take. cold and flu even though I've already taken Zyrtec (cetirizine) about 5 hrs ago?. Took 1/2 zyrtec (cetirizine) 5 hours ago. Is it safe to take 1/2 dose Common Questions and Answers about Can i take zyrtec and nyquil zyrtec I have been sick all week and had a Dr apt today and doc said I can take psuedofed and benedryl just make sure its original. participates with the following insurance plans (please call us if your plan is not listed, as we may still be able to take your insurance). I took a zyrtec Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Anand on can you take dayquil and zyrtec together: they are both antihistamines and would not be useful or safe taken together! Hope this helps Dr z. I was told anything that says tylenol on it i can take and mucinex. So i took tylenol cold & cough. Also you can buy saline mist, which is just salt water & spray it up ur nose to unclog your nose. So i took tylenol cold & cough. Summary. Drug interactions are reported among people who take Nyquil and Zyrtec together. This study is created by eHealthMe based on reports of 43 people who take Nyquil and Zyrtec from FDA, and is updated regularly. You can take Claritin (loratadine) and nyquil on the same day together. Check with your doctor or pharmacist for other options. Check with your doctor or pharmacist for other options. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Chiu on can i take zyrtec and nyquil together: Hello.